Development and validation of an LC-MS/MS method for the simultaneous estimation of tadalafil and macitentan in rat plasma: Greenness assessment and design of experiment approach

This study presents the development and validation of a sensitive LC-MS/MS method for the simultaneous quantification of tadalafil and macitentan in rat plasma, enabling detailed pharmacokinetic profiling following single-dose administration. Optimization of critical parameters, including organic ph...

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Ngā kaituhi matua:	Sravanthi Gandu, Kumaraswamy Gandla, Lalitha Repudi
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Elsevier 2025-03-01
Rangatū:	Green Analytical Chemistry
Ngā marau:	Tadalafil Macitentan LC-MS/MS Rat plasma Design of expert Green analytical chemistry
Urunga tuihono:	http://www.sciencedirect.com/science/article/pii/S2772577425000084
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