CD73 promotes hepatocellular carcinoma progression and metastasis via activating PI3K/AKT signaling by inducing Rap1-mediated membrane localization of P110β and predicts poor prognosis

Abstract Background Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies worldwide because of rapid progression and high incidence of metastasis or recurrence. Accumulating evidence shows that CD73-expressing tumor cell is implicated in development of several types of cancer. How...

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Autors principals:	Xiao-Lu Ma, Min-Na Shen, Bo Hu, Bei-Li Wang, Wen-Jing Yang, Li-Hua Lv, Hao Wang, Yan Zhou, An-Li Jin, Yun-Fan Sun, Chuan-Yan Zhang, Shuang-Jian Qiu, Bai-Shen Pan, Jian Zhou, Jia Fan, Xin-Rong Yang, Wei Guo
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2019-04-01
Col·lecció:	Journal of Hematology & Oncology
Matèries:	Hepatocellular carcinoma CD73 Epithelial-mesenchymal-transition Prognosis PI3K/AKT
Accés en línia:	http://link.springer.com/article/10.1186/s13045-019-0724-7
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