Antiviral therapy: Valacyclovir Treatment of Alzheimer’s Disease (VALAD) Trial: protocol for a randomised, double-blind,placebo-controlled, treatment trial

IntroductionAfter infection, herpes simplex virus-1 (HSV1) becomes latent in the trigeminal ganglion and can enter the brain via retrograde axonal transport. Recurrent reactivation of HSV1 may lead to neurodegeneration and Alzheimer’s disease (AD) pathology. HSV1 (oral herpes) and HSV2 (genital herp...

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Autors principals:	Howard Andrews, D P Devanand, William C Kreisl, Qolamreza Razlighi, Anne Gershon, Yaakov Stern, Akiva Mintz, Thomas Wisniewski, Edward Acosta, Julianna Pollina, Mariasofia Katsikoumbas, Karen L Bell, Gregory H Pelton, Deborah Deliyannides, K M Prasad
Format:	Artigo
Idioma:	Inglês
Publicat:	BMJ Publishing Group 2020-02-01
Col·lecció:	BMJ Open
Accés en línia:	https://bmjopen.bmj.com/content/10/2/e032112.full
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