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ABTB1 modulates EGFR signaling and confers icotinib sensitivity in lung adenocarcinoma

Abstract Background Icotinib is a first-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) widely used in the treatment of EGFR-mutant lung adenocarcinoma (LUAD). However, heterogeneous responses and the development of resistance limit durable clinical benefit. The mo...

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Principais autores: Si-Yang Li, Lu Xia, Peng Xu, Gen-hong Li, Bing-chun Yang, Jing-Xun Wu, Fu-Xing Zhang, Jia-Bian Lian
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2026-04-01
Serier:Respiratory Research
Fag:
Lung adenocarcinoma
Icotinib
EGFR signaling
ABTB1
Drug sensitivity
CRISPR–Cas9 screening
Online adgang:https://doi.org/10.1186/s12931-026-03682-7
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