Reduced Expression of TMEM16A Impairs Nitric Oxide-Dependent Cl− Transport in Retinal Amacrine Cells

Postsynaptic cytosolic Cl− concentration determines whether GABAergic and glycinergic synapses are inhibitory or excitatory. We have shown that nitric oxide (NO) initiates the release of Cl− from acidic internal stores into the cytosol of retinal amacrine cells (ACs) thereby elevating cytosolic Cl−....

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Principais autores:	Tyler Christopher Rodriguez, Li Zhong, Hailey Simpson, Evanna Gleason
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2022-07-01
Colecção:	Frontiers in Cellular Neuroscience
Assuntos:	retina nitric oxide (NO) amacrine cell TMEM16/anoctamin CRISPR/Cas9 intracellular Cl−
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fncel.2022.937060/full
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