Studies in an Early Development Window Unveils a Severe HSC Defect in both Murine and Human Fanconi Anemia

Summary: Fanconi anemia (FA) causes bone marrow failure early during childhood, and recent studies indicate that a hematopoietic defect could begin in utero. We performed a unique kinetics study of hematopoiesis in Fancg−/− mouse embryos, between the early embryonic day 11.5 (E11.5) to E12.5 develop...

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Autori principali:	Carine Domenech, Loïc Maillard, Alix Rousseau, Fabien Guidez, Laurence Petit, Marika Pla, Denis Clay, Fabien Guimiot, Sandra Sanfilippo, Sebastien Jacques, Pierre de la Grange, Noémie Robil, Jean Soulier, Michèle Souyri
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2018-11-01
Serie:	Stem Cell Reports
Accesso online:	http://www.sciencedirect.com/science/article/pii/S2213671118304247
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