A biomimetic model composed of injectable 3D muscle-like tissue, stromal and immune cells for recapitulating the rapid immune signature predictive of mRNA vaccine immunogenicity

BackgroundSystem vaccinology identified an early innate signature associated with vaccine-mediated protection whose induction is likely to involve both immune and non-immune cells.MethodsTo dissect muscle and stromal cell contribution, we simulated in vitro anti-COVID19 BNT162b2 mRNA vaccine intramu...

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Autori principali:	Marilena Paola Etna, Claudia Fuoco, Martina Severa, Daniela Ricci, Alessandro Sinigaglia, Camilla Lucca, Giada Cairo, Barbara Bottazzi, Cecilia Garlanda, Anna Teresa Palamara, Luisa Barzon, Cesare Gargioli, Eliana Marina Coccia
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2025-10-01
Serie:	Frontiers in Immunology
Soggetti:	vaccine muscle cells fibroblasts immune cells innate immune signature in vitro models
Accesso online:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1651095/full
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