Genetic tool for fate mapping of Oct4 (Pou5f1)-expressing cells and their progeny past the pluripotency stage

Abstract Background Methods based on site-specific recombinases are widely used in studying gene activities in vivo and in vitro. In these studies, constitutively active or inducible variants of these recombinases are expressed under the control of either lineage-specific or ubiquitous promoters. Ho...

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Autors principals:	Andrey A. Kuzmin, Veronika V. Ermakova, Sergey A. Sinenko, Sergey V. Ponomartsev, Tatiana Y. Starkova, Elena V. Skvortsova, Olga Cherepanova, Alexey N. Tomilin
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2019-12-01
Col·lecció:	Stem Cell Research & Therapy
Matèries:	Molecular sensor Oct4 Pou5f1 Cre-loxP FlpO-FRT Rosa26
Accés en línia:	https://doi.org/10.1186/s13287-019-1520-6
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