Cancer-specific CTCF binding facilitates oncogenic transcriptional dysregulation

Abstract Background The three-dimensional genome organization is critical for gene regulation and can malfunction in diseases like cancer. As a key regulator of genome organization, CCCTC-binding factor (CTCF) has been characterized as a DNA-binding protein with important functions in maintaining th...

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Λεπτομέρειες βιβλιογραφικής εγγραφής

Κύριοι συγγραφείς:	Celestia Fang, Zhenjia Wang, Cuijuan Han, Stephanie L. Safgren, Kathryn A. Helmin, Emmalee R. Adelman, Valentina Serafin, Giuseppe Basso, Kyle P. Eagen, Alexandre Gaspar-Maia, Maria E. Figueroa, Benjamin D. Singer, Aakrosh Ratan, Panagiotis Ntziachristos, Chongzhi Zang
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	BMC 2020-09-01
Σειρά:	Genome Biology
Θέματα:	CTCF 3D genome organization Integrative analysis Gene regulation Transcription factor Enhancer
Διαθέσιμο Online:	http://link.springer.com/article/10.1186/s13059-020-02152-7
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