Niemann-Pick type C2 protein supplementation in experimental non-alcoholic fatty liver disease.

Hepatic cholesterol deposition drives inflammation and fibrosis in non-alcoholic steatohepatitis (NASH). The Niemann-Pick type C2 (NPC2) protein plays an important role in regulating intracellular cholesterol trafficking and homeostasis. We hypothesized that intravenous NPC2 supplementation reduces...

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Autors principals:	Claus Uhrenholt Christensen, Emilie Glavind, Karen Louise Thomsen, Yong Ook Kim, Sara Heebøll, Detlef Schuppan, Stephen Hamilton-Dutoit, Christian Würtz Heegaard, Henning Grønbæk
Format:	Artigo
Idioma:	Inglês
Publicat:	Public Library of Science (PLoS) 2018-01-01
Col·lecció:	PLoS ONE
Accés en línia:	http://europepmc.org/articles/PMC5844539?pdf=render
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