Timeline of hypoglossal motor neuron death and intrinsic tongue muscle denervation in high-copy number SOD1G93A mice

In amyotrophic lateral sclerosis (ALS) postmortem tissue and the SOD1 mouse model at mid-disease, death of hypoglossal motor neurons (XII MNs) is evident. These XII MNs innervate the intrinsic and extrinsic tongue muscles, and despite their importance in many oral and lingual motor behaviours that a...

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Bibliografische Detailangaben

Hauptverfasser:	Matthew J. Fogarty, Joy R. Drieberg-Thompson, Mark C. Bellingham, Peter G. Noakes
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2024-07-01
Schriftenreihe:	Frontiers in Neurology
Schlagworte:	amyotrophic lateral sclerosis motor neurons neuromuscular junctions hypoglossal tongue
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fneur.2024.1422943/full
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