Modeling integration site data for safety assessment with MELISSA
Abstract Gene and cell therapies pose safety concerns due to potential insertional mutagenesis by viral vectors. We introduce MELISSA, a regression-based statistical framework for analyzing Integration Site (IS) data to assess insertional mutagenesis risk, by estimating and comparing gene-specific i...
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| Principais autores: | , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Portfolio
2025-08-01
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| Serier: | Nature Communications |
| Online adgang: | https://doi.org/10.1038/s41467-025-63017-w |
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