Safety and efficacy of combined treatment with tumor-infiltrating lymphocytes and oncolytic adenovirus TILT-123 in metastatic melanoma

Summary: Tumor-infiltrating lymphocytes (TILs) are effective in the treatment of metastatic melanoma (MM), but toxicity limits its application. TILT-123 (igrelimogene litadenorepvec) is an oncolytic adenovirus producing interleukin-2 (IL-2) and tumor necrosis factor (TNF) upon replication. In this p...

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Autori principali:	Tine J. Monberg, Santeri A. Pakola, Benedetta Albieri, Eva Ellebaek, Marco Donia, Rikke L. Eefsen, Troels H. Borch, Tatiana V. Kudling, Torben Lorentzen, Helle W. Hendel, Cecilie Vestergaard, Cathrine Lorentzen, Rikke B. Holmstroem, Victor Arias, Amir Khammari, Claudia Kistler, João M. Santos, James H.A. Clubb, Lyna Haybout, Marie C.W. Westergaard, Özcan Met, Dafne C.A. Quixabeira, Elise Jirovec, Riikka Havunen, Suvi Sorsa, Victor Cervera-Carrascon, Brigitte Dreno, Akseli Hemminki, Inge Marie Svane
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2025-03-01
Serie:	Cell Reports Medicine
Soggetti:	tumor-infiltrating lymphocytes TIL therapy oncolytic virus therapy cutaneous melanoma uveal melanoma mucosal melanoma
Accesso online:	http://www.sciencedirect.com/science/article/pii/S2666379125000898
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