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A conserved MCM single-stranded DNA binding element is essential for replication initiation

The ring-shaped MCM helicase is essential to all phases of DNA replication. The complex loads at replication origins as an inactive double-hexamer encircling duplex DNA. Helicase activation converts this species to two active single hexamers that encircle single-stranded DNA (ssDNA). The molecular d...

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I tiakina i:
Ngā taipitopito rārangi puna kōrero
Ngā kaituhi matua: Clifford A Froelich, Sukhyun Kang, Leslie B Epling, Stephen P Bell, Eric J Enemark
Hōputu: Artigo
Reo:Inglês
I whakaputaina: eLife Sciences Publications Ltd 2014-04-01
Rangatū:eLife
Ngā marau:
Urunga tuihono:https://elifesciences.org/articles/01993
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