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Inference of SARS-CoV-2 exposure biomarkers using large-scale T-cell repertoire profiling

Abstract Background The COVID-19 pandemic offers a powerful opportunity to develop methods for monitoring the spread of infectious diseases based on their signatures in population immunity. Adaptive immune receptor repertoire sequencing (AIRR-seq) has become the method of choice for identifying T ce...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Elizaveta K. Vlasova, Alexandra I. Nekrasova, Alexander Y. Komkov, Mark Izraelson, Ekaterina A. Snigir, Sergey I. Mitrofanov, Vladimir S. Yudin, Valentin V. Makarov, Anton A. Keskinov, Darya Korneeva, Anastasia Pivnyuk, Pavel V. Shelyakin, Ilgar Z. Mamedov, Denis V. Rebrikov, Sergey M. Yudin, Veronika I. Skvortsova, Dmitry M. Chudakov, Olga V. Britanova, Mikhail Shugay
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2026-02-01
Schriftenreihe:Genome Medicine
Schlagworte:
T cell receptor
Immune repertoires
Immune biomarkers
COVID-19
TCR specificity
Phenotype prediction
Online-Zugang:https://doi.org/10.1186/s13073-025-01589-4
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