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Targeted therapies and PARPi therapy response following ICI therapy failure in advanced melanoma: a case series

Poly (ADP-ribose) polymerase inhibitors (PARPi) have shown efficacy in treating cancers with homologous recombination deficiency (HRD), including subsets of melanoma. However, the potential synergy between PARPi and standard melanoma therapies remains understudied. Here, we report two cases of advan...

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Principais autores: George Nassief, Renee Morecroft, Jordan Phillipps, David Chen, George Ansstas
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis Group 2025-12-01
Serier:Melanoma Management
Fag:
PARPi
BRAFi
PD-L1 inhibitor
advanced melanoma
immunotherapy resistance
case series
Online adgang:https://www.tandfonline.com/doi/10.1080/20450885.2025.2598476
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