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The lncRNA ELDR suppresses tumorigenicity of AML by interfering with DNA replication and chromatin accessibility

Abstract: Acute myeloid leukemia (AML) with rearrangement of the mixed lineage leukemia gene expresses MLL-AF9 fusion protein, a transcription factor that impairs differentiation and drives expansion of leukemic cells. In this work, the zinc finger protein “growth factor independent 1” together with...

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Principais autores: Kaifee Arman, Julie Ross, Eva-Maria Piskor, Luca Lazzari, Virginie Calderon, Gaspard Reulet, Maria Vera, Edlie St-Hilaire, Hugo Wurtele, Brian T. Wilhelm, Tarik Möröy
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2025-12-01
Colecção:Blood Advances
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2473952925005579
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