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Subcutaneous preconditioning increases invasion and metastatic dissemination in mouse colorectal cancer models

Mouse colorectal cancer (CRC) models generated by orthotopic microinjection of human CRC cell lines reproduce the pattern of lymphatic, haematological and transcoelomic spread but generate low metastatic efficiency. Our aim was to develop a new strategy that could increase the metastatic efficiency...

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Principais autores: Patricia Alamo, Alberto Gallardo, Miguel A. Pavón, Isolda Casanova, Manuel Trias, Maria A. Mangues, Esther Vázquez, Antonio Villaverde, Ramon Mangues, Maria V. Céspedes
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists 2014-03-01
coleção:Disease Models & Mechanisms
Assuntos:
Collective invasion
Colorectal cancer model
Metastasis
Orthotopic injection
Single tumour cell
Subcutaneous preconditioning
Acesso em linha:http://dmm.biologists.org/content/7/3/387
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