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Association of pyrazinamide resistance in Mycobacterium tuberculosis with mutations in rpoB, katG, and inhA genes

Abstract Multidrug-resistant tuberculosis (MDR-TB) is associated with a high rate of treatment failure. Since the 9 to 11-month shorter oral regimen in MDR-TB treatment includes pyrazinamide (PZA), it is essential to assess the susceptibility of MDR-TB strains to PZA to guide effective therapy. The...

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Principais autores: Kartiki Srivastava, Salman Khan, Rajniti Prasad, Sada Nand Pandey, Shampa Anupurba
Format: Artigo
Sprog:Inglês
Udgivet: Nature Portfolio 2026-05-01
Serier:Scientific Reports
Fag:
Mycobacterium tuberculosis
Multidrug resistance
Line probe assay
Rifampicin
Isoniazid
Pyrazinamide
Online adgang:https://doi.org/10.1038/s41598-026-53296-8
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