Identification of specific brain cell types associated with the interplay between inflammatory bowel diseases and neuropsychiatric disorders by Cell-Stratified Mendelian RandomisationResearch in context

Summary: Background: Inflammatory bowel disease (IBD) has been suggested to be associated with neuropsychiatric disorders, but the underlying mechanisms remain poorly understood. Methods: We employed Cell-Stratified Mendelian Randomisation (csMR) to analyse genetic variants associated with IBD and...

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Autori principali:	Qi Zhou, Tian Gong, Yiling Wu, Ziwei Zhong, Haitao Deng, Chensong Sun, Xiao Lei, Junpeng Ma, Qihui Zhu, Lingyan Zhu, Chengsheng Zhang
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2025-12-01
Serie:	EBioMedicine
Soggetti:	Inflammatory bowel disease Neuropsychiatric disorders Mendelian randomisation Single-cell eQTL
Accesso online:	http://www.sciencedirect.com/science/article/pii/S2352396425004311
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