Protective effect of dexmedetomidine against organ dysfunction in a two-hit model of hemorrhage/resuscitation and endotoxemia in rats

Dexmedetomidine (DEX), a selective agonist of α2-adrenergic receptors, has anti-inflammation properties and potential beneficial effects against trauma, shock, or infection. Therefore, this study aimed to investigate whether DEX might protect against multiple-organ dysfunction in a two-hit model of...

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Autori principali:	Yuanxu Jiang, Mingzhu Xia, Qiang Huang, Dengfeng Ding, Yali Li, Zhongjun Zhang, Xueping Zhang
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Associação Brasileira de Divulgação Científica 2019-02-01
Serie:	Brazilian Journal of Medical and Biological Research
Soggetti:	Hemorrhagic shock Resuscitation Endotoxemia Dexmedetomidine Yohimbine
Accesso online:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019000300604&lng=en&tlng=en
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