Inhibition of PDE‐4 isoenzyme attenuates frequency and overall contractility of agonist‐evoked ureteral phasic contractions

Abstract The aim of this study was to investigate the functional role of phosphodiesterase enzymes (PDE) in the isolated porcine ureter. Distal ureteral strips were mounted in organ baths and pre‐contracted with 5‐HT (100 μM). Upon generation of stable phasic contractions, PDE‐4 and PDE‐5 inhibitors...

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Bibliografski detalji

Glavni autori:	Iris Lim, Taishi Masutani, Hikaru Hashitani, Russ Chess‐Williams, Donna Sellers
Format:	Artigo
Jezik:	Inglês
Izdano:	Wiley 2024-02-01
Serija:	Pharmacology Research & Perspectives
Teme:	phasic contractions phosphodiesterase phosphodiesterase inhibitors roflumilast rolipram sildenafil
Online pristup:	https://doi.org/10.1002/prp2.1175
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