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Dopamine activates NF-κB and primes the NLRP3 inflammasome in primary human macrophages

Induction of innate immune genes in the brain is thought to be a major factor in the development of addiction to substances of abuse. As the major component of the innate immune system in the brain, aberrant activation of myeloid cells such as macrophages and microglia due to substance use may media...

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Principais autores: R.A. Nolan, K.L. Reeb, Y. Rong, S.M. Matt, H.S. Johnson, K. Runner, P.J. Gaskill
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2020-02-01
Serier:Brain, Behavior, & Immunity - Health
Fag:
Dopamine
Macrophages
Neuroinflammation
NLRP3
Drug abuse
NF-κB
Online adgang:http://www.sciencedirect.com/science/article/pii/S2666354619300316
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