Heterogeneity of Phenotype and Function Reflects the Multistage Development of T Follicular Helper Cells

T follicular helper cells (Tfh) provide crucial signals for germinal center (GC) formation, but Tfh populations are heterogeneous. While PD1hi Tfh are important in the GC response, the function of the PD1lo Tfh-like subset is unknown. We show that these cells, like the PD1hi GC–Tfh, depend upon B ce...

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Autors principals:	David Gray, Marta Trüb, Tom A. Barr, Vicky L. Morrison, Sheila Brown, Stefano Caserta, Jordan Rixon, Alasdair Ivens
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2017-04-01
Col·lecció:	Frontiers in Immunology
Matèries:	T follicular helper cells T cell memory T follicular helper cell subsets germinal centres T cell heterogeneity
Accés en línia:	http://journal.frontiersin.org/article/10.3389/fimmu.2017.00489/full
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