BDNF is altered in a brain-region specific manner and rescues deficits in Spinocerebellar Ataxia Type 1

Spinocerebellar ataxia type 1 (SCA1) is an adult-onset, dominantly inherited neurodegenerative disease caused by the expanded polyQ tract in the protein ATAXIN1 (ATXN1) and characterized by progressive motor and cognitive impairments. There are no disease-modifying treatments or cures for SCA1. Brai...

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Autores principales:	Juao-Guilherme Rosa, Katherine Hamel, Alyssa Soles, Carrie Sheeler, Ella Borgenheimer, Stephen Gilliat, Kaelin Sbrocco, Ferris Ghanoum, Hillary P. Handler, Colleen Forster, Orion Rainwater, Marija Cvetanovic
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Elsevier 2023-03-01
Colección:	Neurobiology of Disease
Materias:	SCA1 BDNF Neurodegeneration Brain region specific Motor deficits Cognition
Acceso en línea:	http://www.sciencedirect.com/science/article/pii/S0969996123000372
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