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Reduced Childhood Outdoor Exposure Raises Pediatric Multiple Sclerosis (PedMS) Risk

Abstract Introduction Sun exposure may influence MS susceptibility, but evidence in pediatric-onset MS (PedMS) is limited. We examined whether reduced early-childhood outdoor time (a proxy for lower sun exposure) is associated with PedMS risk. Methods In the Italian multicenter PEDIGREE Study, envir...

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Autori principali: Silvy Pilotto, Angelo Ghezzi, Stefania Maria Bova, Marzia Fronza, Pietro Annovazzi, Marta Simone, Antonio Gallo, Agnese Suppiej, Roberta Lanzillo, Sarah Rasia, Angela Berardinelli, Valentina Torri Clerici, Lucia Moiola, Maurizio Viri, Stefano Sotgiu, Simona Malucchi, Alessandra Protti, Carlotta Canavese, Giacomo Lus, Luigi M. E. Grimaldi, Marta Zaffira Conti, Giovanna Borriello, Giovanna De Luca, Valentina Tomassini, Alberto Priori, Martina Tosi, Nicola Pomella, Andrea Corona, Alen Zollo, Maria Pia Amato, Eleonora Cocco, Maria Trojano, Filippo Martinelli-Boneschi, Sandra D’Alfonso, Roberto Bergamaschi, Maura Pugliatti, and the PEDIGREE Study Group
Natura: Artigo
Lingua:Inglês
Pubblicazione: Adis, Springer Healthcare 2026-05-01
Serie:Neurology and Therapy
Soggetti:
Multiple sclerosis
Pediatrics
Epidemiology
Risk factors
Time spent outdoors
Sun exposure
Accesso online:https://doi.org/10.1007/s40120-026-00956-6
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