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A conformational change of C-reactive protein drives neutrophil extracellular trap formation in inflammation

Abstract Background C-reactive protein (CRP) represents a routine diagnostic marker of inflammation. Dissociation of native pentameric CRP (pCRP) into the monomeric structure (mCRP) liberates proinflammatory features, presumably contributing to excessive immune cell activation via unknown molecular...

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Автори: Ebru Karasu, Rebecca Halbgebauer, Lena Schütte, Johannes Greven, Felix M. Bläsius, Johannes Zeller, Oscar Winninger, David Braig, David Alexander Christian Messerer, Bettina Berger, Hendrik Feuerstein, Anke Schultze, Karlheinz Peter, Uwe Knippschild, Klemens Horst, Frank Hildebrand, Steffen U. Eisenhardt, Markus Huber-Lang
Формат: Artigo
Мова:Inglês
Опубліковано: BMC 2025-01-01
Серія:BMC Biology
Предмети:
C-reactive-protein (CRP)
Monomeric CRP (mCRP)
Neutrophil activation
Neutrophil extracellular trap (NET)
Inflammation
Severe injury
Онлайн доступ:https://doi.org/10.1186/s12915-024-02093-8
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