pSTAT3 transactivates EGFR in maintaining EGFR protein homeostasis and EGFR-TKI resistance

EGFR protein trafficking is critical for regulating multiple biological processes, including cell growth and survival. However, how EGFR protein homeostasis is maintained remains unclear. In this study, we show that a reduction in plasma membrane-associated EGFR triggers EGFR transcription by promot...

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Detalhes bibliográficos

Principais autores:	Ao Juan, Fei Junjie, Wang Guoqiang, Zhang Wenhua, Yu Shuhan, Guo Rongtian, Niu Mengmeng, Chen Hu, Cao Yang, Xiao Zhi-Xiong Jim, Yi Yong
Formato:	Artigo
Idioma:	Inglês
Publicado em:	China Science Publishing & Media Ltd. 2024-09-01
Colecção:	Acta Biochimica et Biophysica Sinica
Assuntos:	EGFR pSTAT3 protein homeostasis EGFR-TKI resistance
Acesso em linha:	https://www.sciengine.com/doi/10.3724/abbs.2024166
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