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411 Molecular dynamics driving phenotypic divergence among KRAS mutants in pancreatic tumorigenesis

Objectives/Goals: To investigate how distinct KRAS mutations (G12D, G12V, and G12R) drive distinct molecular and phenotypic programs in pancreatic tumorigenesis, linking early lineage and signaling differences to clinical patterns such as stage at diagnosis, nodal status, and survival to ultimately...

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Автори: David Falvo, Adrien Grimont, David J Falvo, Whitney J Sisso, Paul Zumbo, Christopher W Chan, Francisco Santos, Grace Pan, Megan Cleveland, Tomer M Yaron, Alexa Osterhoudt, Yinuo Meng, Maria Paz Zafra, William B Fall, Andre F Rendeiro, Erika Hissong, Rhonda K Yantiss, Doron Betel, Mark A Magnuson, Steven D Leach, Anil K Rustgi, Lukas E Dow, Rohit Chandwani
Формат: Artigo
Мова:Inglês
Опубліковано: Cambridge University Press 2026-04-01
Серія:Journal of Clinical and Translational Science
Онлайн доступ:https://www.cambridge.org/core/product/identifier/S2059866126105640/type/journal_article
Теги: Додати тег
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