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Engineering viral protease-operated nanobodies for programmable and orthogonal control of protein function

Abstract Precise control of protein function in living cells is essential for engineering programmable biological systems and therapeutic applications. However, most current strategies act indirectly by altering protein stability, localization, or proximity rather than directly modulating binding ac...

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Bibliografische gegevens
Hoofdauteurs: Mingguang Cui, Xiaoxuan Liu, Tien-Hung Lan, Tianlu Wang, Tatsuki Nonomura, Brendan McKee, Rui Wang, Yun Huang, Yubin Zhou
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Portfolio 2026-07-01
Reeks:Nature Communications
Online toegang:https://doi.org/10.1038/s41467-026-76122-1
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