Structural and dynamic insights revealing how lipase binding domain MD1 of Pseudomonas aeruginosa foldase affects lipase activation

Abstract Folding and cellular localization of many proteins of Gram-negative bacteria rely on a network of chaperones and secretion systems. Among them is the lipase-specific foldase Lif, a membrane-bound steric chaperone that tightly binds (K D = 29 nM) and mediates folding of the lipase LipA, a vi...

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Detalhes bibliográficos

Principais autores:	Aldino Viegas, Peter Dollinger, Neha Verma, Jakub Kubiak, Thibault Viennet, Claus A. M. Seidel, Holger Gohlke, Manuel Etzkorn, Filip Kovacic, Karl-Erich Jaeger
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2020-02-01
coleção:	Scientific Reports
Acesso em linha:	https://doi.org/10.1038/s41598-020-60093-4
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