RNAi-Based Identification of Gene-Specific Nuclear Cofactor Networks Regulating Interleukin-1 Target Genes

The potent proinflammatory cytokine interleukin (IL)-1 triggers gene expression through the NF-κB signaling pathway. Here, we investigated the cofactor requirements of strongly regulated IL-1 target genes whose expression is impaired in p65 NF-κB-deficient murine embryonic fibroblasts. By two indepe...

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Hlavní autoři:	Johanna Meier-Soelch, Liane Jurida, Axel Weber, Doris Newel, Johnny Kim, Thomas Braun, M. Lienhard Schmitz, Michael Kracht
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2018-04-01
Edice:	Frontiers in Immunology
Témata:	IL-1 corepressor coactivator NF-κB transcription chromatin
On-line přístup:	http://journal.frontiersin.org/article/10.3389/fimmu.2018.00775/full
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