The C-terminus of the oncoprotein TGAT is necessary for plasma membrane association and efficient RhoA-mediated signaling

Abstract Background Rho guanine exchange factors (RhoGEFs) control cellular processes such as migration, adhesion and proliferation. Alternative splicing of the RhoGEF Trio produces TGAT. The RhoGEF TGAT is an oncoprotein with constitutive RhoGEF activity. We investigated whether the subcellular loc...

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主要な著者:	J. van Unen, D. Botman, T. Yin, Y. I. Wu, M. A. Hink, T. W. J. Gadella, M. Postma, J. Goedhart
フォーマット:	Artigo
言語:	Inglês
出版事項:	BMC 2018-06-01
シリーズ:	BMC Cell Biology
オンライン･アクセス:	http://link.springer.com/article/10.1186/s12860-018-0155-2
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