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Physiological Metals Can Induce Conformational Changes in Transthyretin Structure: Neuroprotection or Misfolding Induction?

Transthyretin (TTR) is a plasma homotetrameric protein that transports thyroxine and retinol. TTR itself, under pathological conditions, dissociates into partially unfolded monomers that aggregate and form fibrils. Metal ions such as Zn<sup>2+</sup>, Cu<sup>2+</sup>, Fe<sup>2+</sup>, Mn<sup>2+</sup>...

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Autores principales: Lidia Ciccone, Nicolò Tonali, William Shepard, Susanna Nencetti, Elisabetta Orlandini
Formato: Artigo
Lenguaje:Inglês
Publicado: MDPI AG 2021-03-01
Colección:Crystals
Materias:
transthyretin
neuroprotection
metal ions
altered conformations
amyloidoisis
Aβ scavenger
Acceso en línea:https://www.mdpi.com/2073-4352/11/4/354
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