Supplementation with endogenous healthy gut metabolites reverses the disruptions of in vitro and ex vivo epithelial functions induced by fecal content from IBD patients

Despite epithelial involvement in inflammatory bowel disease (IBD) pathogenesis and the gaps in treatment goals with existing immune-directed therapy, epithelial-directed interventions are unavailable. Using patient-based models, we aimed to identify bioactive endogenous metabolites that can improve...

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Hlavní autoři:	Haya Abbas-Egbariya, Lubna Elwahidi, David Jessula Levy, Tzipi Braun, Nina Levhar, Rotem Hadar, Gilat Efroni, Maya Granot, Yael Leichtmann-Bardogoo, Ben M. Maoz, Batia Weiss, Ohad Gal-Mor, Bella Agranovich, Ifat Abramovich, Lee Denson, Shomron Ben-Horin, Kelli L. VanDussen, Amnon Amir, Yael Haberman
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Taylor & Francis Group 2025-12-01
Edice:	Gut Microbes
Témata:	Inflammatory bowel disease (IBD) metabolites epithelia microbiome
On-line přístup:	https://www.tandfonline.com/doi/10.1080/19490976.2025.2597568
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