TCR-mimic bispecific nanobody-based T cell engager targeting intracellular tumor antigens for cancer immunotherapy

Abstract T cell engager (TCE) immunotherapies have revolutionized the landscape of cancer treatment; however, their efficacy remains limited by the inaccessibility of intracellular tumor antigens. Conventional bispecific T cell engagers, typically constructed from aggregation-prone single-chain vari...

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Detalhes bibliográficos

Principais autores:	Ziqiang Ding, Shuyang Sun, Xiaomei Yang, Xianing Huang, Xiaoqiong Hou, Shenxia Xie, Aiqun Liu, Xiaoling Lu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Publishing Group 2026-06-01
coleção:	Signal Transduction and Targeted Therapy
Acesso em linha:	https://doi.org/10.1038/s41392-026-02745-x
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