Steap4 Promotes Senile Osteoporosis via Fe2+‐ROS/C/EBPβ Feedback‐Driven Ferroptosis and Adipogenesis in Senescent BMSCs

Abstract Senile osteoporosis (SOP) is a systemic bone disease characterized by increased susceptibility to fractures. In this study, it is found that senescent bone marrow mesenchymal stem cells (BMSCs) exhibit increased sensitivity to ferroptosis, a phenomenon associated with Steap4, a nicotinamide...

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Autores principales:	Liangliang Wang, Guangrong Yin, Wenming Li, Maoyuan Li, Feng Lu, Chao Xu, Gongyin Zhao, Dechun Geng, Jiaxiang Bai, Yuji Wang
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Wiley 2026-01-01
Colección:	Advanced Science
Materias:	BMSCs ferroptosis osteoporosis senescence Steap4
Acceso en línea:	https://doi.org/10.1002/advs.202509926
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