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Copper-enriched automotive brake wear particles perturb human alveolar cellular homeostasis

Abstract Background Airborne fine particulate matter with diameter < 2.5 μm (PM2.5), can reach the alveolar regions of the lungs, and is associated with over 4 million premature deaths per year worldwide. However, the source-specific consequences of PM2.5 exposure remain poorly understood. A major,...

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Hauptverfasser: James G. H. Parkin, Lareb S. N. Dean, Joseph A. Bell, Natasha H. C. Easton, Liam J. Edgeway, Matthew J. Cooper, Robert Ridley, Franco Conforti, Siyuan Wang, Liudi Yao, Juanjuan Li, Helen Vethakan Raj, Julian Downward, Miriam Gerlofs-Nijland, Flemming R. Cassee, Yihua Wang, Richard B. Cook, Mark G. Jones, Donna E. Davies, Matthew Loxham
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2025-02-01
Schriftenreihe:Particle and Fibre Toxicology
Schlagworte:
Brake-wear PM
Non-exhaust emissions
Non-tailpipe emissions
Alveolar
Epithelium
Pseudohypoxic signalling
Online-Zugang:https://doi.org/10.1186/s12989-024-00617-2
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