Osteoblast-secreted collagen upregulates paracrine Sonic hedgehog signaling by prostate cancer cells and enhances osteoblast differentiation

<p>Abstract</p> <p>Background</p> <p>Induction of osteoblast differentiation by paracrine Sonic hedgehog (Shh) signaling may be a mechanism through which Shh-expressing prostate cancer cells initiate changes in the bone microenvironment and promote metastases. A hallmark of osteoblast differentiatio...

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Autori principali:	Zunich Samantha M, Valdovinos Maria, Douglas Taneka, Walterhouse David, Iannaccone Philip, Lamm Marilyn LG
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2012-07-01
Serie:	Molecular Cancer
Soggetti:	Prostate cancer Bone metastasis Hedgehog Collagen Extracellular matrix Osteoblast differentiation
Accesso online:	http://www.molecular-cancer.com/content/11/1/30
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