Exon 3 of the NUMB Gene Emerged in the Chordate Lineage Coopting the NUMB Protein to the Regulation of MDM2

MDM2 regulates a variety of cellular processes through its dual protein:protein interaction and ubiquitin ligase activities. One major function of MDM2 is to bind and ubiquitinate P53, thereby regulating its proteasomal degradation. This function is in turn controlled by the cell fate determinant NU...

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Hlavní autoři:	Stefano Confalonieri, Ivan Nicola Colaluca, Andrea Basile, Salvatore Pece, Pier Paolo Di Fiore
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Oxford University Press 2019-10-01
Edice:	G3: Genes, Genomes, Genetics
Témata:	NUMB MDM2 exon gain chordate evolution PTB domain
On-line přístup:	http://g3journal.org/lookup/doi/10.1534/g3.119.400494
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