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The Mechanism of Action of SAAP-148 Antimicrobial Peptide as Studied with NMR and Molecular Dynamics Simulations

Background: SAAP-148 is an antimicrobial peptide derived from LL-37. It exhibits excellent activity against drug-resistant bacteria and biofilms while resisting degradation in physiological conditions. Despite its optimal pharmacological properties, its mechanism of action at the molecular level has...

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Main Authors: Morgane Adélaïde, Evgeniy Salnikov, Francisco Ramos-Martín, Christopher Aisenbrey, Catherine Sarazin, Burkhard Bechinger, Nicola D’Amelio
Format: Artigo
Language:Inglês
Published: MDPI AG 2023-02-01
Series:Pharmaceutics
Subjects:
antimicrobial
peptides
biomembranes
NMR
molecular dynamics
paramagnetic relaxation enhancement
Online Access:https://www.mdpi.com/1999-4923/15/3/761
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