Host E3 ubiquitin ligase ITCH mediates Toxoplasma gondii effector GRA35-triggered NLRP1 inflammasome activation and cell-autonomous immunity

ABSTRACT Toxoplasma gondii is an intracellular parasite that can activate the NLRP1 inflammasome leading to macrophage pyroptosis in Lewis rats, but the underlying mechanism is not well understood. In this study, we performed a genome-wide CRISPR screen and identified the dense granule proteins GRA3...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Yifan Wang, L. Robert Hollingsworth, Lamba Omar Sangaré, Tatiana C. Paredes-Santos, Shruthi Krishnamurthy, Bennett H. Penn, Hao Wu, Jeroen P. J. Saeij
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology 2024-03-01
Schriftenreihe:	mBio
Schlagworte:	E3 ubiquitin ligase effector-triggered immunity NLRP1 inflammasome IFNγ Toxoplasma gondii
Online-Zugang:	https://journals.asm.org/doi/10.1128/mbio.03302-23
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