Spinal RAMP1-mediated neuropathic pain sensitisation in the aged mice through the modulation of CGRP-CRLR pain signalling

Pain sensitivity varies depending on both the state and age of an individual. For example, chronic pain is more common in older individuals, but the underlying mechanisms remain unknown. This study revealed that 18-month-old mice (aged) experienced more severe and long-lasting allodynia and hyperalg...

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Hlavní autoři:	Yi Qin, Xuemei Chen, Zhangjie Yu, Xiaoxin Zhou, Yihao Wang, Qi Li, Wanbing Dai, Yizhe Zhang, Sa Wang, Yinghui Fan, Jie Xiao, Diansan Su, Yingfu Jiao, Weifeng Yu
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2024-08-01
Edice:	Heliyon
Témata:	Ageing Spinal dorsal horn (SDH) Chronic pain CGRP RAMP1
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S2405844024118932
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