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Mechanism of effector capture and delivery by the type IV secretion system from Legionella pneumophila

A membrane-embedded complex (called T4CC) is essential for injection of Legionella pneumophila effector proteins into human macrophages via a Type IV secretion system. Here, the authors purify and study the T4CC using functional and cryo-EM structural analyses, providing insights into the secretion...

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主要な著者: Amit Meir, Kevin Macé, Natalya Lukoyanova, David Chetrit, Manuela K. Hospenthal, Adam Redzej, Craig Roy, Gabriel Waksman
フォーマット: Artigo
言語:Inglês
出版事項: Nature Portfolio 2020-06-01
シリーズ:Nature Communications
オンライン・アクセス:https://doi.org/10.1038/s41467-020-16681-z
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