Comparative analysis of antibody-mediated loss-of-function versus gene knock-out and knock-down

In this study we compare three methods for manipulating cell function: RNA interference (RNAi), CRISPR-Cas9 gene knock-out, and antibody-mediated loss-of-function. We have focused on analyzing changes in cell-matrix adhesion via targeting two key regulators, Talin1 (TLN1) and Kindlin-2 (KD2). Adhesi...

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Главные авторы:	Marie Buck-Wiese, Sally Liechocki, Holger Erfle, Vytaute Starkuviene
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Elsevier 2025-12-01
Серии:	SLAS Discovery
Предметы:	Antibody delivery Cell adhesion Kindlin, Talin, Off-target effect
Online-ссылка:	http://www.sciencedirect.com/science/article/pii/S2472555225000760
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