p60-S6K1 represents a novel kinase active isoform with the mode of regulation distinct from p70/p85-S6K1 isoforms

The phosphatidylinositol-3-kinase (PI3K)/mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway controls plenty of cellular functions regulating phosphorylation one of its mediators ribosomal protein S6 kinase 1 (S6K1). Alternative translation of the common S6K1 transcript can generate...

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Bibliografische Detailangaben

Hauptverfasser:	I. V. Zaiets, V. V. Holiar, A. S. Sivchenko, V. V. Smialkovska, V. V. Filonenko
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry 2019-08-01
Schriftenreihe:	The Ukrainian Biochemical Journal
Schlagworte:	kinase activity p60-S6 kinase 1 (p60-S6K1) PI3K/mTORC1 signaling pathway regulation by protein phosphorylation
Online-Zugang:	http://ukrbiochemjournal.org/wp-content/uploads/2019/06/Zaiets_4_19.pdf
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