Genetic silencing of KCa3.1 inhibits atherosclerosis in ApoE null mice

Increased expression of KCa3.1 has been found in vascular smooth muscle cells (SMC), macrophages, and T cells in atherosclerotic lesions from humans and mice. Pharmacological inhibition of KCa3.1 in limiting atherosclerosis has been demonstrated in mice and pigs, however direct, loss-of-function, i....

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Autori principali: P. Alam, D. L. Tharp, H. J. Bowles, L. A. Grisanti, H. Bui, S. B. Bender, D. K. Bowles
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis Group 2025-12-01
Serie:Channels
Soggetti:
KCa3.1
gene silencing
brachiocephalic artery
atherosclerosis
macrophage
PPAR signaling
Accesso online:https://www.tandfonline.com/doi/10.1080/19336950.2025.2538864
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