Csk-homologous kinase (Chk) is an efficient inhibitor of Src-family kinases but a poor catalyst of phosphorylation of their C-terminal regulatory tyrosine

Abstract Background C-terminal Src kinase (Csk) and Csk-homologous kinase (Chk) are the major endogenous inhibitors of Src-family kinases (SFKs). They employ two mechanisms to inhibit SFKs. First, they phosphorylate the C-terminal tail tyrosine which stabilizes SFKs in a closed inactive conformation...

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Autors principals:	Gahana Advani, Ya Chee Lim, Bruno Catimel, Daisy Sio Seng Lio, Nadia L. Y. Ng, Anderly C. Chüeh, Mai Tran, Mohd Ishtiaq Anasir, Heather Verkade, Hong-Jian Zhu, Benjamin E. Turk, Thomas E. Smithgall, Ching-Seng Ang, Michael Griffin, Heung-Chin Cheng
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2017-08-01
Col·lecció:	Cell Communication and Signaling
Matèries:	Src-family protein kinases Tumor suppressor Catalysis, colon cancer C-terminal Src kinase Csk Chk
Accés en línia:	http://link.springer.com/article/10.1186/s12964-017-0186-x
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