Senescent bone marrow mesenchymal stem cells exacerbate subchondral bone sclerosis and osteoarthritis via the senescence-associated secretory phenotype

Abstract Background Osteoarthritis (OA) is a common joint disease characterized by articular cartilage degeneration, with subchondral bone sclerosis being a key pathological change. However, the mechanism underlying subchondral bone sclerosis remains unclear. Senescent stem cells have been found in...

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Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Dinglong Yang, Xin Xu, Ke Xu, Mingyi Yang, Yangquan Hao, Yirixiati Aihaiti, Erliang Li, Yuheng Yan, Chao Lu, Peng Xu
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	BMC 2025-11-01
Цуврал:	Stem Cell Research & Therapy
Нөхцлүүд:	Osteoarthritis Subchondral bone BMSC SASP Senescence
Онлайн хандалт:	https://doi.org/10.1186/s13287-025-04833-1
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!