Targeting the JAK2V617F mutant hematopoietic microenvironment in myeloproliferative neoplasm
The acquired JAK2V617F mutation is predominantly detected in hematopoietic stem cells(HSCs), leading to myeloproliferative neoplasms(MPN). Emerging evidence shows that JAK2V617F bearing cells remodel their microenvironment by dysregulating cytokines, and altering adhesion molecules, with histopathol...
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| Natura: | Artigo |
| Lingua: | Inglês |
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Frontiers Media S.A.
2026-01-01
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| Serie: | Frontiers in Hematology |
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| Accesso online: | https://www.frontiersin.org/articles/10.3389/frhem.2025.1694867/full |
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